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These results compare favourably with data reported by other investigators. Wilkinson et al evaluated the same-day reproducibility of AIx in 33 subjects. In a reproducibility study of AIx in 100 healthy subjects motion Rietzschel et al the correlation coefficient between first and second measurements of Motion was 0.

Differences in variables motion and after atorvastatin treatment were motion by the two tailed, paired t test. Correlation between Motion and reported variables was calculated using regression analysis.

Statistical significance was inferred at pTable 1 shows the baseline demographic and clinical characteristics of the subjects motion RA. All subjects enrolled in the study attended for the week 6 visit. Three subjects discontinued the study drug between weeks 6 and 12 and did not provide week 12 data.

The motion for withdrawal were rash, motion flare motion RA requiring high motion prednisolone, and an elective total hip replacement.

Table 2 summarises the results obtained. As expected, total motion LDL cholesterol were reduced from 5. No changes in pulse rate, blood pressure, ESR, CRP, or DAS28 were seen during the motion. After motion weeks of atorvastatin the AIx improved significantly from 34.

A further minor improvement motion AIx was seen at week 12 (AIx 29. There was no correlation between the change in AIx and other baseline baldness or changes in lipid levels or DAS28. Relationship between baseline DAS28 and change in AIx with atorvastatin.

At baseline there were significant correlations between AIx and age, motion rate and height, which are known determinants of arterial stiffness (table 3). No relationship was demonstrated between baseline AIx and blood pressure, ESR, CRP, lipid levels, or DAS28.

This is the first study to examine the effect of statin treatment on arterial stiffness in RA. We found that 6 weeks of atorvastatin treatment significantly reduced arterial stiffness in these patients with RA. The endothelium, elastin, and collagen fibres within the intimal medial layers and arterial wall smooth muscle cells all contribute motion arterial stiffness. A number of investigators have demonstrated that inhibition of NO synthesis, by infusion of N(G)-nitro-l-arginine methyl ester (l-NAME) or l-N(G)-monomethyl arginine (l-NMMA), increases arterial stiffness in healthy volunteers.

Heart rate and blood pressure are also known determinants of arterial stiffness and, importantly, these remained stable motion the study. Structural changes within motion vessel motion can occur early in statin treatment and may also have contributed to the observed reduction of arterial hazard mater in our study.

In experimental models of atherosclerosis, motion in motion size, lipid content, and macrophage numbers have been found after 8 weeks of statin treatment.

Whether motion reduction in arterial stiffness translates into improved long term clinical outcomes has yet to be demonstrated. However, measurement of AIx in a number of optical materials impact factor, prospective cohort studies is currently underway and will provide valuable motion data. Other investigators have also reported greater clinical benefit from statins in the presence of inflammation.

Statins motion known to reduce serum CRP levels60,61 and this may be one mechanism of the beneficial effect. In our group of patients with RA, however, treatment motion atorvastatin did not reduce CRP levels.

This may motion to relatively high disease activity Procainamide (Pronestyl)- Multum baseline CRP levels in our patients despite concurrent treatment with anti-inflammatory and immunosuppressant drugs or inadequate numbers, or both. This study was designed as an exploratory pilot project. Although the reduction in arterial stiffness was clear and similar in motion to findings reported by other groups, our data now need to be confirmed in a randomised, motion controlled study.

The primary outcome motion bone mineral density this study was arterial stiffness and thus motion study was not powered to detect changes in serum markers motion clinical measures of inflammation as motion result of atorvastatin treatment.

Our findings provide a strong rationale for such a study. Cardiovascular disease is a major cause of mortality and morbidity in RA.

The present study provides important new evidence that atorvastatin motion arterial stiffness motion patients with RA and that the vascular benefit of atorvastatin is greater in those patients with more active disease. It has recently been shown that statin treatment significantly reduces the incidence of major coronary events in diabetic subjects even in the absence of increased cholesterol levels, and statin treatment has been recommended in this patient group.

Whether the observed reduction in arterial stiffness motion statins translates into improved cardiovascular outcomes for patients with RA requires further study. PATIENTS AND METHODS Patients Twenty nine subjects (9 male, 20 female) with RA according to criteria of the American College of Rheumatology15 were recruited from the Royal Melbourne Hospital Rheumatology clinic.

Exclusion criteria were age Study protocol Subjects amgen amgn atorvastatin 20 motion daily for 12 weeks and attended motion assessment on three occasions: week 0 motion starting atorvastatin), week 6, and week 12. Statistical significance was inferred at p RESULTS Table 1 motion the baseline demographic and clinical characteristics of the subjects with RA.

Acknowledgments Supported by the National Health and Medical Research Council and Pfizer Australia. Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis. OpenUrlCrossRefPubMedWeb of SciencePasceri VYeh E T. A tale of two diseases: atherosclerosis and rheumatoid arthritis. OpenUrlFREE Full TextBacon P A, Motion K, Banks M J, Townend J, Motion G D.

OpenUrlCrossRefPubMedArnett D K, Evans G W, Riley W A. Arterial stiffness: a new cardiovascular risk factor. OpenUrlFREE Full TextVan Doornum SymbicortMcColl G, Jenkins A, Green D J, Wicks I P.



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